The Anti-SRP1/KPNA1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to KPNA1. This antibody recognizes Human, Mouse, and Rat antigen. The Anti-SRP1/KPNA1 Antibody has been validated for the following applications: Cell Sorting, Isolation, Flow Cytometry, Immunocytochemistry, Immunofluorescence, and Western Blot.
Description
Importin subunit alpha-1 is a protein that in humans is encoded by the KPNA1 gene. The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants